In Vitro Anti-Helicobacter pylori Activity of Irisolidone Isolated from the Flowers and Rhizomes of Pueraria thunbergiana

Eun-Ah Bae; Myung Joo Han; Dong-Hyun Kim

doi:10.1055/s-2001-11499

Planta Medica, Table of Contents

Planta Med 2001; 67(2): 161-163
DOI: 10.1055/s-2001-11499

Letter

In Vitro Anti-Helicobacter pylori Activity of Irisolidone Isolated from the Flowers and Rhizomes of Pueraria thunbergiana

Eun-Ah Bae¹ , Myung Joo Han¹ , Dong-Hyun Kim^2,*

¹ Department of Food and Nutrition, Kyung-Hee University, Dongdaemun-ku, Seoul, Korea
² College of Pharmacy, Kyung-Hee University, Dongdaemun-ku, Seoul, Korea

Abstract

The inhibitory effect of isoflavones isolated from the flowers and rhizomes of Pueraria thunbergiana (Leguminosae) on the growth of Helicobacter pylori (HP) was investigated. Isoflavone glycosides did not inhibit the growth of HP. However, their aglycones, irisolidone, tectorigenin and genistein, inhibited HP growth. Among them, irisolidone had the most potent inhibitory activity against HP and its MIC was 12.5 - 25 μg/ml. Genistein only weakly inhibited the urease of HP and H⁺/K⁺-ATPase of rat stomach: its IC₅₀ were 0.43 and 0.89 mg/ml, respectively

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Prof. Dr. D.-H. Kim

College of Pharmacy,

Kyung-Hee University

1, Hoegi

Dongdaemum-ku

Seoul 130-701

Korea

Email: dhkim@nms.kyunghee.ac.kr

Fax: +82-2-957-5030